dc.contributor.authorChang, Eric H.
dc.contributor.authorVolpe, Bruce T.
dc.contributor.authorMackay, Meggan
dc.contributor.authorAranow, Cynthia
dc.contributor.authorWatson, Philip
dc.contributor.authorKowal, Czeslawa
dc.contributor.authorStorbeck, Justin
dc.contributor.authorMattis, Paul
dc.contributor.authorBerlin, RoseAnn
dc.contributor.authorChen, Huiyi
dc.contributor.authorMader, Simone
dc.contributor.authorHuerta, Tomás S.
dc.contributor.authorHuerta, Patricio T.
dc.contributor.authorDiamond, Betty
dc.date.accessioned2015-09-18T08:38:02Z
dc.date.available2015-09-18T08:38:02Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.identifier.citationChang, E. H., Volpe, B. T., Mackay, M., Aranow, C., Watson, P., Kowal, C., et al. (2015). Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor. EBioMedicine, 2(7), 755-764.en_US
dc.identifier.issn2352-3964en_US
dc.identifier.urihttp://hdl.handle.net/10220/38717
dc.description.abstractPatients with systemic lupus erythematosus (SLE) experience cognitive abnormalities in multiple domains including processing speed, executive function, and memory. Here we show that SLE patients carrying antibodies that bind DNA and the GluN2A and GluN2B subunits of the N-methyl-d-aspartate receptor (NMDAR), termed DNRAbs, displayed a selective impairment in spatial recall. Neural recordings in a mouse model of SLE, in which circulating DNRAbs penetrate the hippocampus, revealed that CA1 place cells exhibited a significant expansion in place field size. Structural analysis showed that hippocampal pyramidal cells had substantial reductions in their dendritic processes and spines. Strikingly, these abnormalities became evident at a time when DNRAbs were no longer detectable in the hippocampus. These results suggest that antibody-mediated neurocognitive impairments may be highly specific, and that spatial cognition may be particularly vulnerable to DNRAb-mediated structural and functional injury to hippocampal cells that evolves after the triggering insult is no longer present.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesEBioMedicineen_US
dc.rights© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.titleSelective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptoren_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)
dc.identifier.doihttp://dx.doi.org/10.1016/j.ebiom.2015.05.027
dc.description.versionPublished versionen_US


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