Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/103510
Title: Unconventional Bifunctional Lewis-Brønsted Acid Activation Mode in Bicyclic Guanidine-Catalyzed Conjugate Addition Reactions
Authors: Cho, Bokun
Wong, Ming Wah
Issue Date: 2015
Source: Cho, B., & Wong, M. W. (2015). Unconventional Bifunctional Lewis-Brønsted Acid Activation Mode in Bicyclic Guanidine-Catalyzed Conjugate Addition Reactions. Molecules, 20(8), 15108-15121.
Series/Report no.: Molecules
Abstract: DFT calculations have demonstrated that the unconventional bifunctional Brønsted-Lewis acid activation mode is generally applicable to a range of nucleophilic conjugate additions catalyzed by bicyclic guanidine catalysts. It competes readily with the conventional bifunctional Brønsted acid mode of activation. The optimal pro-nucleophiles for this unconventional bifunctional activation are acidic substrates with low pKa, while the best electrophiles are flexible 1,4-diamide and 1,4-diester conjugated systems.
URI: https://hdl.handle.net/10356/103510
http://hdl.handle.net/10220/38773
ISSN: 1420-3049
DOI: http://dx.doi.org/10.3390/molecules200815108
Rights: © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
metadata.item.grantfulltext: open
metadata.item.fulltext: With Fulltext
Appears in Collections:ERI@N Journal Articles

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