dc.contributor.authorMockenhaupt, Stefan
dc.contributor.authorMakeyev, Eugene V.
dc.date.accessioned2015-11-30T08:14:58Z
dc.date.available2015-11-30T08:14:58Z
dc.date.issued2015
dc.identifier.citationMockenhaupt, S., & Makeyev, E. V. (2015). Non-coding functions of alternative pre-mRNA splicing in development. Seminars in Cell & Developmental Biology, 47–48, 32–39.en_US
dc.identifier.issn1084-9521en_US
dc.identifier.urihttp://hdl.handle.net/10220/38867
dc.description.abstractA majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.format.extent8 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesSeminars in cell & developmental biologyen_US
dc.rights© 2015 Published by Elsevier Ltd. Open Access funded by Biotechnology and Biological Sciences Research Council. Under a Creative Commons licenseen_US
dc.subjectAlternative pre-mRNA splicingen_US
dc.subjectmRNA stabilityen_US
dc.subjectTranslational regulationen_US
dc.subjectmRNA localizationen_US
dc.subjectDevelopmenten_US
dc.titleNon-coding functions of alternative pre-mRNA splicing in developmenten_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.semcdb.2015.10.018
dc.description.versionPublished versionen_US


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