dc.contributor.authorHamid, Fursham M.
dc.contributor.authorMakeyev, Eugene V.
dc.identifier.citationHamid, F., & Makeyev, E. (2014). Emerging functions of alternative splicing coupled with nonsense-mediated decay. Biochemical Society Transactions, 42(4), 1168-1173.en_US
dc.description.abstractHigher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cytoplasmic quality control mechanism eliminating mRNAs containing PTCs (premature translation termination codons). Although originally identified as an error surveillance process, AS-NMD additionally provides an efficient strategy for deterministic regulation of gene expression outputs. In this review, we discuss recently published examples of AS–NMD and delineate functional contexts where recurrent use of this mechanism orchestrates expression of important genes.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.format.extent8 p.en_US
dc.relation.ispartofseriesBiochemical society transactionsen_US
dc.rights© The Authors Journal compilation © 2014 Biochemical Societyen_US
dc.subjectPhysiological responseen_US
dc.subjectPost-transcriptional regulation of gene expressionen_US
dc.subjectRNA metabolismen_US
dc.titleEmerging functions of alternative splicing coupled with nonsense-mediated decayen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionPublished versionen_US

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