dc.contributor.authorAstorga, Guadalupe
dc.contributor.authorBao, Jin
dc.contributor.authorMarty, Alain
dc.contributor.authorAugustine, George James
dc.contributor.authorFranconville, Romain
dc.contributor.authorJalil, Abdelali
dc.contributor.authorBradley, Jonathan
dc.contributor.authorLlano, Isabel
dc.date.accessioned2015-12-10T08:16:23Z
dc.date.available2015-12-10T08:16:23Z
dc.date.issued2015
dc.identifier.citationAstorga, G., Bao, J., Marty, A., Augustine, G. J., Franconville, R., Jalil, A., et al. (2015). An excitatory GABA loop operating in vivo. Frontiers in Cellular Neuroscience, 9, 275-.en_US
dc.identifier.issn1662-5102en_US
dc.identifier.urihttp://hdl.handle.net/10220/39040
dc.description.abstractWhile it has been proposed that the conventional inhibitory neurotransmitter GABA can be excitatory in the mammalian brain, much remains to be learned concerning the circumstances and the cellular mechanisms governing potential excitatory GABA action. Using a combination of optogenetics and two-photon calcium imaging in vivo, we find that activation of chloride-permeable GABAA receptors in parallel fibers (PFs) of the cerebellar molecular layer of adult mice causes parallel fiber excitation. Stimulation of PFs at submaximal stimulus intensities leads to GABA release from molecular layer interneurons (MLIs), thus creating a positive feedback loop that enhances excitation near the center of an activated PF bundle. Our results imply that elevated chloride concentration can occur in specific intracellular compartments of mature mammalian neurons and suggest an excitatory role for GABAA receptors in the cerebellar cortex of adult mice.en_US
dc.format.extent14 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesFrontiers in Cellular Neuroscienceen_US
dc.rights© 2015 Astorga, Bao, Marty, Augustine, Franconville, Jalil, Bradley and Llano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectCalciumen_US
dc.subjectGABAen_US
dc.subjectCerebellumen_US
dc.subjectParallel fibersen_US
dc.subjectInterneuronsen_US
dc.titleAn excitatory GABA loop operating in vivoen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicine
dc.identifier.doihttp://dx.doi.org/10.3389/fncel.2015.00275
dc.description.versionPublished versionen_US


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