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|Title:||A preclinical evaluation of an autologous living hyaline-like cartilaginous graft for articular cartilage repair: a pilot study||Authors:||Peck, Yvonne
Chilla, Geetha Soujanya V. N.
Poh, Chueh Loo
|Issue Date:||2015||Source:||Peck, Y., He, P., Chilla, G. S. V. N., Poh, C. L., & Wang, D.-A. (2015). A preclinical evaluation of an autologous living hyaline-like cartilaginous graft for articular cartilage repair: a pilot study. Scientific Reports, 5, 16225-.||Series/Report no.:||Scientific Reports||Abstract:||In this pilot study, an autologous synthetic scaffold-free construct with hyaline quality, termed living hyaline cartilaginous graft (LhCG), was applied for treating cartilage lesions. Implantation of autologous LhCG was done at load-bearing regions of the knees in skeletally mature mini-pigs for 6 months. Over the course of this study, significant radiographical improvement in LhCG treated sites was observed via magnetic resonance imaging. Furthermore, macroscopic repair was effected by LhCG at endpoint. Microscopic inspection revealed that LhCG engraftment restored cartilage thickness, promoted integration with surrounding native cartilage, produced abundant cartilage-specific matrix molecules, and re-established an intact superficial tangential zone. Importantly, the repair efficacy of LhCG was quantitatively shown to be comparable to native, unaffected cartilage in terms of biochemical composition and biomechanical properties. There were no complications related to the donor site of cartilage biopsy. Collectively, these results imply that LhCG engraftment may be a viable approach for articular cartilage repair.||URI:||https://hdl.handle.net/10356/81060
|ISSN:||2045-2322||DOI:||http://dx.doi.org/10.1038/srep1622510.1038/srep16225||Rights:||This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SCBE Journal Articles|
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