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|Title:||Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents||Authors:||Jackson, Alexander W.
Rannard, Steven P.
branched copolymer nanoparticles
|Issue Date:||2015||Source:||Jackson, A. W., Chandrasekharan, P., Shi, J., Rannard, S. P., Liu, Q., Yang, C.-T., et al. (2015). Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents. International Journal of Nanomedicine, 10, 5895-5907.||Series/Report no.:||International Journal of Nanomedicine||Abstract:||Branched copolymer nanoparticles (Dh =20–35 nm) possessing 1,4,7, 10-tetraazacyclododecane-N,N',N",N'"-tetraacetic acid macrocycles within their cores have been synthesized and applied as magnetic resonance imaging (MRI) nanosized contrast agents in vivo. These nanoparticles have been generated from novel functional monomers via reversible addition–fragmentation chain transfer polymerization. The process is very robust and synthetically straightforward. Chelation with gadolinium and preliminary in vivo experiments have demonstrated promising characteristics as MRI contrast agents with prolonged blood retention time, good biocompatibility, and an intravascular distribution. The ability of these nanoparticles to perfuse and passively target tumor cells through the enhanced permeability and retention effect is also demonstrated. These novel highly functional nanoparticle platforms have succinimidyl ester-activated benzoate functionalities within their corona, which make them suitable for future peptide conjugation and subsequent active cell-targeted MRI or the conjugation of fluorophores for bimodal imaging. We have also demonstrated that these branched copolymer nanoparticles are able to noncovalently encapsulate hydrophobic guest molecules, which could allow simultaneous bioimaging and drug delivery.||URI:||https://hdl.handle.net/10356/81040
|ISSN:||1176-9114||DOI:||http://dx.doi.org/10.2147/IJN.S88764||Rights:||© 2015 Jackson et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
SCBE Journal Articles
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