dc.contributor.authorGao, Fei
dc.contributor.authorOng, Yi Hong
dc.contributor.authorLi, Gaoming
dc.contributor.authorFeng, Xiaohua
dc.contributor.authorLiu, Quan
dc.contributor.authorZheng, Yuanjin
dc.date.accessioned2016-01-07T04:36:13Z
dc.date.available2016-01-07T04:36:13Z
dc.date.issued2015
dc.identifier.citationGao, F., Ong, Y. H., Li, G., Feng, X., Liu, Q., & Zheng, Y. (2015). Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study. Optics Letters, 40(15), 3568-3571.en_US
dc.identifier.issn0146-9592en_US
dc.identifier.urihttp://hdl.handle.net/10220/39610
dc.description.abstractIn this Letter, photoacoustic-guided Raman spectroscopy (PARS) is proposed for a fast depth-resolved Raman measurement with accurate depth localization. The approach was experimentally demonstrated to receive both photoacoustic and Raman signals from a three-layer agar phantom based on a developed synergic photoacoustic-Raman probe, showing strong depth correlation and achieving magnitude of faster operation speed due to photoacoustic time-of-flight measurement and guidance, compared with the conventional depth-resolved Raman spectroscopy method. In addition, further combination with advanced optical-focusing techniques in biological-scattering medium could potentially enable the proposed approach for cancer diagnostics with both tight and fast optical focusing at the desired depth of tumor.en_US
dc.format.extent5 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesOptics Lettersen_US
dc.rights© 2015 Optical Society of America. This paper was published in Optics Letters and is made available as an electronic reprint (preprint) with permission of Optical Society of America. The published version is available at: [http://dx.doi.org/10.1364/OL.40.003568]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en_US
dc.subjectRaman spectroscopy
dc.subjectDepth-resolved
dc.titleFast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility studyen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1364/OL.40.003568
dc.description.versionAccepted versionen_US


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