dc.contributor.authorLi, Nan
dc.contributor.authorWang, Xuewan
dc.contributor.authorChen, Jie
dc.contributor.authorSun, Lei
dc.contributor.authorChen, Peng
dc.identifier.citationLi, N., Wang, X., Chen, J., Sun, L., & Chen, P. (2015). Graphene quantum dots for ultrasensitive detection of acetylcholinesterase and its inhibitors. 2D Materials, 2(3), 034018-.en_US
dc.description.abstractGraphene quantum dots (GQDs) are emerging zero-dimensional materials promising a wide spectrum of novel applications including development of optical sensors. Herein, a GQD-based fluorometric sensor is devised to detect acetylcholinesterase (AChE, a critical enzyme in central nervous system and neuromuscular junctions) with an ultralow detection limit (0.58 pM with S/N of 5.0), using a photoluminescence 'turn-off' mechanism. This simple 'mix-and-detect' platform can also be employed to sense a variety of compounds that can directly or indirectly inhibit the enzymatic activities of AChE, such as nerve gases, pesticides, and therapeutic drugs. As the proof-of-concept demonstrations, we show the sensitive detection of paraoxon (a pesticide), tacrine (a drug to treat Alzheimer's disease), and dopamine (an important neurotransmitter).en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent21 p.en_US
dc.relation.ispartofseries2D Materialsen_US
dc.rights© 2015 IOP Publishing Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by 2D Materials, IOP Publishing Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1088/2053-1583/2/3/034018].en_US
dc.subject2D Materials
dc.subjectFluorometric sensor
dc.titleGraphene quantum dots for ultrasensitive detection of acetylcholinesterase and its inhibitorsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.versionAccepted versionen_US

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