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      Butelase-mediated synthesis of protein thioesters and its application for tandem chemoenzymatic ligation

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      Butelase-mediated synthesis of protein thioesters and its application for tandem chemoenzymatic ligation.pdf (645.2Kb)
      Author
      Cao, Yuan
      Nguyen, Kien Truc Giang
      Tam, James P.
      Liu, Chuan-Fa
      Date of Issue
      2015
      School
      School of Biological Sciences
      Version
      Accepted version
      Abstract
      Using a recently discovered peptide ligase, butelase 1, we developed a novel method to access protein thioesters in good yield. We successfully combined it with native chemical ligation and sortase-mediated ligation in tandem for protein C-terminal labeling and dual-terminal labeling to exploit the orthogonality of these three ligation methods.
      Subject
      thioester
      catalytic efficiency
      Type
      Journal Article
      Series/Journal Title
      Chemical Communications
      Rights
      © 2015 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Chemical Communications, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C5CC07227A].
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      http://dx.doi.org/10.1039/C5CC07227A
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