Regulatory RNAs discovered in unexpected places
Pek, Jun Wei
Date of Issue2015-10-01
School of Biological Sciences
Recent studies have discovered both small and long noncoding RNAs (ncRNAs) encoded in unexpected places. These ncRNA genes were surprises at the time of their discovery, but many quickly became well-accepted families of functional regulatory RNA species. Even after years of extensive gene annotation studies using high-throughput sequencing technologies, new types of ncRNA genes continue to be discovered in unexpected places. We highlight ncRNAs that have atypical structures and that are encoded in what are generally considered 'junk' sequences, such as spacers and introns. We also discuss current bottlenecks in the approaches for identifying novel ncRNAs and the possibility that many remain to be discovered.
Wiley Interdisciplinary Reviews: RNA
© 2015 Wiley Periodicals, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Wiley Interdisciplinary Reviews: RNA, 2015 Wiley Periodicals, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/wrna.1309].