dc.contributor.authorKannadorai, Ravi Kumar
dc.contributor.authorChiew, Geraldine Giap Ying
dc.contributor.authorLuo, Kathy Qian
dc.contributor.authorLiu, Quan
dc.date.accessioned2016-01-22T03:32:36Z
dc.date.available2016-01-22T03:32:36Z
dc.date.issued2014
dc.identifier.citationKannadorai, R. K., Chiew, G. G. Y., Luo, K. Q., & Liu, Q. (2014). Dual functions of gold nanorods as photothermal agent and autofluorescence enhancer to track cell death during plasmonic photothermal therapy. Cancer Letters, 357(1), 152-159.en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10220/39751
dc.description.abstractGold nanorods have the potential to localize the treatment procedure by hyperthermia and influence the fluorescence. The longitudinal plasmon peak contributes to the photothermal effect by converting light to heat. When these nanorods are PEGylated, it not only makes it biocompatible but also acts as a spacer layer during fluorescence enhancement. When the PEGylated nanorods are internalized inside the cells through endocytosis, the transverse plasmonic peak combined with the enhanced absorption and scattering properties of the nanorods can enhance the autofluorescence emission intensity from the cell. The autofluorescence from the mitochondria inside cells which reflects the respiratory status of the cell was enhanced two times by the presence of nanorods within the cell. At four minutes, the nanorods incubated cells reached the hyperthermic temperature when illuminated continuously with near infrared laser. The cell viability test and autofluorescence intensity curve showed a similar trend indicating the progress of cell death over time. This is the first report to the best of our knowledge to suggest the potential of exploiting the dual capabilities of gold nanorods as photothermal agents and autofluorescence enhancer to track cell death.en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.format.extent24 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesCancer Lettersen_US
dc.rights© 2014 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Cancer Letters, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.canlet.2014.11.022].en_US
dc.subjectPhotothermal therapyen_US
dc.subjectHyperthermia
dc.subjectGold nanorods
dc.subjectNecrosis
dc.subjectAutofluorescence
dc.subjectRenal cell carcinoma
dc.titleDual functions of gold nanorods as photothermal agent and autofluorescence enhancer to track cell death during plasmonic photothermal therapyen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2014.11.022
dc.description.versionAccepted versionen_US


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