Bioinspired pH and magnetic responsive catechol-functionalized chitosan hydrogels with tunable elastic properties
Author
Ghadban, Ali
Ahmed, Anansa S.
Ping, Yuan
Ramos, Ricardo
Arfin, Najmul
Cantaert, Bram
Ramanujan, Raju Vijayaraghavan
Miserez, Ali
Date of Issue
2015-10-30School
School of Materials Science and Engineering
School of Biological Sciences
School of Biological Sciences
Research Centre
Centre for Biomimetic Sensor Science
Version
Published version
Abstract
We have developed pH- and magnetic-responsive hydrogels that are stabilized by both covalent bonding and catechol/Fe3+ ligands. The viscoelastic properties of the gels are regulated by the complexation valence and can be used to tune drug release profiles. The stable incorporation of magnetic nanoparticles further expands control over the mechanical response and drug release, in addition to providing magnetic stimuli-responsivity to the gels.
Subject
Drug release
Type
Journal Article
Series/Journal Title
Chemical Communications
Rights
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Collections
http://dx.doi.org/10.1039/C5CC08617E
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