dc.contributor.authorSharma, Vijay Kumar
dc.contributor.authorAlipour, A.
dc.contributor.authorSoran-Erdem, Z.
dc.contributor.authorAykut, Z. G.
dc.contributor.authorDemir, Hilmi Volkan
dc.identifier.citationSharma, V. K., Alipour, A., Soran-Erdem, Z., Aykut, Z. G., & Demir, H. V. (2015). Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents. Nanoscale, 7(23), 10519-10526.en_US
dc.description.abstractWe report the first study of highly monodisperse and crystalline iron oxide nanocubes with sub-nm controlled size distribution (9.7 ± 0.5 nm in size) that achieve simultaneous contrast enhancement in both T1- and T2-weighted magnetic resonance imaging (MRI). Here, we confirmed the magnetite structure of iron oxide nanocubes by X-ray diffraction (XRD), selected area electron diffraction (SAED) pattern, optical absorption and Fourier transformed infrared (FT-IR) spectra. These magnetite nanocubes exhibit superparamagnetic and paramagnetic behavior simultaneously by virtue of their finely controlled shape and size. The magnetic measurements reveal that the magnetic moment values are favorably much lower because of the small size and cubic shape of the nanoparticles, which results in an enhanced spin canting effect. As a proof-of-concept demonstration, we showed their potential as dual contrast agents for both T1- and T2-weighted MRI via phantom studies, in vivo imaging and relaxivity measurements. Therefore, these low-magnetization magnetite nanocubes, while being non-toxic and bio-compatible, hold great promise as excellent dual-mode T1 and T2 contrast agents for MRI.en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.format.extent8 p.en_US
dc.rightsThis article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.en_US
dc.titleHighly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agentsen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.description.versionPublished versionen_US

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