dc.contributor.authorMathiyazhakan, Malathi
dc.contributor.authorChan, Weiwei
dc.contributor.authorOhl, Claus-Dieter
dc.contributor.authorXu, Chenjie
dc.date.accessioned2016-03-18T07:30:59Z
dc.date.available2016-03-18T07:30:59Z
dc.date.issued2016
dc.identifier.citationMathiyazhakan, M., Chan, W., Ohl, C.-D., & Xu, C. (2016). Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation. Journal of Visualized Experiments, (108), e53619-.en_US
dc.identifier.issn1940-087Xen_US
dc.identifier.urihttp://hdl.handle.net/10220/40305
dc.description.abstractPhoto-responsive nanoparticles (NPs) have received considerable attention because of their potential in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the development process and are unprocurable by clinics. Here, we describe a facile fabrication of these photo-responsive NPs with commercially available gold NPs and thermo-responsive liposomes Calcein is used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Finally, we show that this photo-triggered release is due to the membrane disruption caused by microbubble cavitation, which can be measured with hydrophone.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent5 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesJournal of Visualized Experimentsen_US
dc.rights© 2016 Journal of Visualized Experiments. This paper was published in Journal of Visualized Experiments and is made available as an electronic reprint (preprint) with permission of Journal of Visualized Experiments. The published version is available at: [http://dx.doi.org/10.3791/53619]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en_US
dc.subjectBioengineeringen_US
dc.subjectIssue 108en_US
dc.subjectExogenous stimuli-responsive nanoparticlesen_US
dc.subjectlight-responsive liposomesen_US
dc.subjectgold nanoparticlesen_US
dc.subjectdrug deliveryen_US
dc.subjectcontrolled releaseen_US
dc.subjectmicrobubble cavitationen_US
dc.titleSynthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitationen_US
dc.typeJournal Article
dc.contributor.researchNTU-Northwestern Institute of Nanomedicine
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.3791/53619
dc.description.versionPublished versionen_US


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