Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/82825
Title: Modulating Drug Release from Gastric-Floating Microcapsules through Spray-Coating Layers
Authors: Lee, Wei Li
Tan, Jun Wei Melvin
Tan, Chaoyang Nicholas
Loo, Say Chye Joachim
Keywords: Coatings
Drug delivery
Polymers
Buoyancy
Drug-drug interaction
Vegetable oils
Drug absorption
Microencapsulation
Issue Date: 2014
Source: Lee, W. L., Tan, J. W. M., Tan, C. N., & Loo, S. C. J. (2014). Modulating Drug Release from Gastric-Floating Microcapsules through Spray-Coating Layers. PLoS ONE, 9(12), e114284-.
Series/Report no.: PLoS ONE
Abstract: Floating dosage forms with prolonged gastric residence time have garnered much interest in the field of oral delivery. However, studies had shown that slow and incomplete release of hydrophobic drugs during gastric residence period would reduce drug absorption and cause drug wastage. Herein, a spray-coated floating microcapsule system was developed to encapsulate fenofibrate and piroxicam, as model hydrophobic drugs, into the coating layers with the aim of enhancing and tuning drug release rates. Incorporating fenofibrate into rubbery poly(caprolactone) (PCL) coating layer resulted in a complete and sustained release for up to 8 h, with outermost non-drug-holding PCL coating layer serving as a rate-controlling membrane. To realize a multidrug-loaded system, both hydrophilic metformin HCl and hydrophobic fenofibrate were simultaneously incorporated into these spray-coated microcapsules, with metformin HCl and fenofibrate localized within the hollow cavity of the capsule and coating layer, respectively. Both drugs were observed to be completely released from these coated microcapsules in a sustained manner. Through specific tailoring of coating polymers and their configurations, piroxicam loaded in both the outer polyethylene glycol and inner PCL coating layers was released in a double-profile manner (i.e. an immediate burst release as the loading dose, followed by a sustained release as the maintenance dose). The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid, and provided controlled and sustained release, thus revealing its potential as a rate-controlled oral drug delivery
URI: https://hdl.handle.net/10356/82825
http://hdl.handle.net/10220/40329
ISSN: 1932-6203
DOI: http://dx.doi.org/10.1371/journal.pone.0114284
Rights: © 2014 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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