dc.contributor.authorZhong, Liang
dc.contributor.authorGhista, Dhanjoo N.
dc.contributor.authorNg, Yin Kwee
dc.contributor.authorLim, Soo Teik
dc.contributor.authorChua, Siang Jin
dc.identifier.citationZhong, L., Ghista, D. N., Ng, Y. K., Lim, S. T., & Chua, S. J. (2005). Measures and Indices for Intrinsic Characterization of Cardiac Dysfunction during Filling & Systolic Ejection. Journal of Mechanics in Medicine and Biology, 5(2), 307-332.en_US
dc.description.abstractThe paper discusses the development and application of bioengineering indices for reliable diagnosis of cardiac functional modalities in filling and contraction phases. During diastolic filling, the left-ventricular (LV) volume developed is a response to left-atrium (LV) suction at early rapid filling and LA contraction at late filling. However, in LV ejection, the LV flow-rate and aortic pressure constitute response to LV myocardial stress and intra-LV pressure generation. The differential equations used in the governing of these relationships have been developed. By matching the solutions of these differential equations with the clinical data of LV volume and pressure, we can determine the heart model "differential equations" parameters, as well as the derived indices. These parameters and indices include: compliance and resistance-to-filling for characterizing diastolic-filling function, together with the index of LV contractility (in terms of maximum LV contractile power and stress-velocity relationship for contractile element). By evaluating them, it is possible to diagnose more reliably and differentially heart diseases due to an increase in filling-resistance and contractility abnormalities.en_US
dc.format.extent37 p.en_US
dc.relation.ispartofseriesJournal of Mechanics in Medicine and Biologyen_US
dc.rights© 2005 World Scientific Publishing Company. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Mechanics in Medicine and Biology, World Scientific Publishing Company. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1142/S0219519405001369].en_US
dc.subjectHeart failureen_US
dc.subjectventricular functionen_US
dc.titleMeasures and Indices for Intrinsic Characterization of Cardiac Dysfunction during Filling & Systolic Ejectionen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.description.versionAccepted versionen_US

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