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|Title:||Virus-specific T lymphocytes home to the skin during natural dengue infection||Authors:||Rivino, Laura
Kumaran, Emmanuelle A.
Too, Chien Tei
Gan, Victor Chih Hao
Hanson, Brendon J.
Gascoigne, Nicholas R. J.
Lye, David Chien
Leo, Yee Sin
Akbar, Arne N.
Kemeny, David M.
MacAry, Paul A.
|Keywords:||Medicine||Issue Date:||2015||Source:||Rivino, L., Kumaran, E. A., Thein, T. L., Too, C. T., Gan, V. C. H., Hanson, B. J., et al. (2015). Virus-specific T lymphocytes home to the skin during natural dengue infection. Science Translational Medicine, 7(278), 278ra35-.||Series/Report no.:||Science Translational Medicine||Abstract:||Dengue, which is the most prevalent mosquito-borne viral disease afflicting human populations, causes a spectrum of clinical symptoms that include fever, muscle and joint pain, maculopapular skin rash, and hemorrhagic manifestations. Patients infected with dengue develop a broad antigen-specific T lymphocyte response, but the phenotype and functional properties of these cells are only partially understood. We show that natural infection induces dengue-specific CD8+ T lymphocytes that are highly activated and proliferating, exhibit antiviral effector functions, and express CXCR3, CCR5, and the skin-homing marker cutaneous lymphocyte-associated antigen (CLA). In the same patients, bystander human cytomegalovirus –specific CD8+ T cells are also activated during acute dengue infection but do not express the same tissue-homing phenotype. We show that CLA expression by circulating dengue-specific CD4+ and CD8+ T cells correlates with their in vivo ability to traffic to the skin during dengue infection. The juxtaposition of dengue-specific T cells with virus-permissive cell types at sites of possible dengue exposure represents a previously uncharacterized form of immune surveillance for this virus. These findings suggest that vaccination strategies may need to induce dengue-specific T cells with similar homing properties to provide durable protection against dengue viruses.||URI:||https://hdl.handle.net/10356/82909
|ISSN:||1946-6234||DOI:||http://dx.doi.org/10.1126/scitranslmed.aaa0526||Rights:||© 2015 American Association for the Advancement of Science. This is the author created version of a work that has been peer reviewed and accepted for publication by Science Translational Medicine, American Association for the Advancement of Science. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1126/scitranslmed.aaa0526].||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
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|Virus-specific T lymphocytes home to the skin during natural dengue infection.pdf||Main article||1.78 MB||Adobe PDF|
|Virus-specific T lymphocytes_Supplementary material_Figure 1.pdf||Supplementary data 1||635.81 kB||Adobe PDF|
|Virus-specific T lymphocytes_Supplementary material_Figure 2.pdf||Supplementary data 2||790.6 kB||Adobe PDF|
|Virus-specific T lymphocytes_Supplementary material_Figure 3.pdf||Supplementary data 3||671.12 kB||Adobe PDF|
|Virus-specific T lymphocytes_Supplementary material_Figure 4.pdf||Supplementary data 4||624.75 kB||Adobe PDF|
|Virus-specific T lymphocytes_Supplementary material_Figure 5.pdf||Supplementary data 5||597.51 kB||Adobe PDF|
|Virus-specific T lymphocytes_Supplementary material_Figure 6.pdf||Supplementary data 6||666.83 kB||Adobe PDF|
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