Artemisinin resistance in Plasmodium falciparum
Ferreira, Pedro E
Date of Issue2014
School of Biological Sciences
Benoit Witkowski and colleagues reported a simple and rapid in vitro method to detect artemisinin resistance of P falciparum. They show that the slow clearance of parasites by artemisinin combination therapies is a result of a drop in susceptibility among young ring form parasites whereas susceptibility is maintained in mature stages. However, the clinical relevance of this finding to treatment failure is unclear since these infections could still be successfully treated with artemisinin combination therapies.
The Lancet Infectious Diseases
© 2014 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Lancet Infectious Diseases, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/S1473-3099(14)70706-6].