Lee, Raymond Teck Ho
Ingham, Philip William
Date of Issue2016
Lee Kong Chian School of Medicine
The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extends across many fields, from evo-devo to cancer research and regenerative medicine. Here, and in the accompanying poster, we provide an outline of the current understanding of Hh signalling mechanisms, highlighting the similarities and differences between species.
© 2016 The Author(s). (published by The Company of Biologists Ltd.). This paper was published in Development and is made available as an electronic reprint (preprint) with permission of The Company of Biologists Ltd. The published version is available at: [http://dx.doi.org/10.1242/dev.120154]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.