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https://hdl.handle.net/10356/80269
Title: | Palladium-Catalyzed Alkynylation and Concomitant ortho Alkylation of Aryl Iodides | Authors: | Lei, Chuanhu Jin, Xiaojia Zhou, Jianrong (Steve) |
Keywords: | alkynylation CH activation Catellani reaction benzofuran palladium catalysis |
Issue Date: | 2016 | Source: | Lei, C., Jin, X., & Zhou, J. (2016). Palladium-Catalyzed Alkynylation and Concomitant ortho Alkylation of Aryl Iodides. ACS Catalysis, 6(3), 1635-1639. | Series/Report no.: | ACS Catalysis | Abstract: | We report an efficient alkynylation reaction of aryl iodides with simultaneous ortho-alkylaton of aryl rings. The reaction between three simple reagents—aryl halides, alkynes, and alkyl halides—formed aryl–alkynyl bonds carrying hindered aryl rings in one step. The reaction proceeded via a Catellani-type pathway in the presence of norbornene. From a synthetic perspective, this reaction allows quick access toward many 1,2,3-substituted arenes and multiply substituted benzofurans, after manipulation of alkyne groups. These compounds are difficult to synthesize otherwise. | URI: | https://hdl.handle.net/10356/80269 http://hdl.handle.net/10220/40513 |
ISSN: | 2155-5435 | DOI: | 10.1021/acscatal.6b00169 | Schools: | School of Physical and Mathematical Sciences | Rights: | © 2016 American Chemical Society. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SPMS Journal Articles |
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