Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides
Zhou, Jianrong (Steve)
Date of Issue2015
School of Physical and Mathematical Sciences
Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl–heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thiophenes underwent efficient coupling. The heteroarenes were deprotonated in situ by bases without the assistance of palladium catalysts.
Angewandte Chemie International Edition
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