Monocyte cell membrane-derived nanoghosts for targeted cancer therapy
Gnanasammandhan, M. K.
Cui, M. Y.
Chan, J. M.
Date of Issue2016
School of Chemical and Biomedical Engineering
Core-shell type ‘nanoghosts’ were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h dox0rubicin loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.
© 2016 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.