dc.contributor.authorChong, Mark Seow Khoon
dc.date.accessioned2016-05-20T08:53:16Z
dc.date.available2016-05-20T08:53:16Z
dc.date.issued2015
dc.identifier.citationChong, M. S. K. (2015). Experimental models of bone metastasis: Opportunities for the study of cancer dormancy. Advanced Drug Delivery Reviews, 94, 141-150.en_US
dc.identifier.issn0169-409Xen_US
dc.identifier.urihttp://hdl.handle.net/10220/40559
dc.description.abstractSkeletal metastasis is prevalent in many cancers, and has been the subject of intense research, yielding innovative models to study the multiple stages of metastasis. It is now evident that, in the early stages of metastatic spread, disseminated tumour cells in the bone undergo an extended period of growth arrest in response to the microenvironment, a phenomenon known as “dormancy”. Dormancy has been implicated with drug resistance, while enforced dormancy has also been seen as a radical method to control cancer, and engineering of dormant states has emerged as a novel clinical strategy. Understanding of the subject, however, is limited by the availability of models to describe early stages of metastatic spread. This mini-review provides a summary of experimental models currently being used in the study of bone metastasis and the applications of these models in the study of dormancy. Current research in developing improved models is described, leading to a discussion of challenges involved in future developments.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.format.extent32 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAdvanced Drug Delivery Reviewsen_US
dc.rights© 2016 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Drug Delivery Reviews, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.addr.2014.12.007].en_US
dc.subjectMetastasisen_US
dc.subjectExperimental modelsen_US
dc.subjectCanceren_US
dc.subjectBoneen_US
dc.subjectDormancyen_US
dc.subjectDisseminated tumour cellsen_US
dc.titleExperimental models of bone metastasis: Opportunities for the study of cancer dormancyen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.addr.2014.12.007
dc.description.versionAccepted versionen_US


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