Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80669
Title: Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma
Authors: Wang, Qi
Sun, Ying
Zhang, Zhirong
Duan, Yourong
Keywords: Liver tumors
Polymeric therapeutic nanoparticles
Apoptosis pathway
Cell membrane potential
Issue Date: 2015
Source: Wang, Q., Sun, Y., Zhang, Z., & Duan, Y. (2015). Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials, 56, 229-240.
Series/Report no.: Biomaterials
Abstract: Nanoparticles (NPs) have great potential as drug delivery systems or as drugs for treating certain diseases. We designed three NPs with different charges and modifications with PEG to treat tumors. PDLA-CS, PEG-PLGA-PLL, and PEG-PS/CaP NPs were designed and evaluated to assess NPs fate in vivo and efficacy for treating tumors. Comparison between PEG-modified and non-PEG-modified NPs showed that PEG-modified NPs increased K+ efflux, easily escaped from lysosomes, affected the mitochondria, induced mitochondrial apoptosis, had longer circulation time, and easily targeted tumors. Non-PEG-modified NPs induce the endoplasmic reticulum apoptosis pathway. Comparison between positively and negatively charged NPs showed that negatively charged NPs have less effect on the K+ efflux of normal cells and more effect on the mitochondrial apoptosis of tumor cells. Positively charged NPs accumulated within the tumors and the liver and lungs. These results provide a theoretical basis for future clinical applications.
URI: https://hdl.handle.net/10356/80669
http://hdl.handle.net/10220/40625
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2015.03.050
Rights: © 2015 Elsevier.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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