dc.contributor.authorWang, Qi
dc.contributor.authorSun, Ying
dc.contributor.authorZhang, Zhirong
dc.contributor.authorDuan, Yourong
dc.identifier.citationWang, Q., Sun, Y., Zhang, Z., & Duan, Y. (2015). Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials, 56, 229-240.en_US
dc.description.abstractNanoparticles (NPs) have great potential as drug delivery systems or as drugs for treating certain diseases. We designed three NPs with different charges and modifications with PEG to treat tumors. PDLA-CS, PEG-PLGA-PLL, and PEG-PS/CaP NPs were designed and evaluated to assess NPs fate in vivo and efficacy for treating tumors. Comparison between PEG-modified and non-PEG-modified NPs showed that PEG-modified NPs increased K+ efflux, easily escaped from lysosomes, affected the mitochondria, induced mitochondrial apoptosis, had longer circulation time, and easily targeted tumors. Non-PEG-modified NPs induce the endoplasmic reticulum apoptosis pathway. Comparison between positively and negatively charged NPs showed that negatively charged NPs have less effect on the K+ efflux of normal cells and more effect on the mitochondrial apoptosis of tumor cells. Positively charged NPs accumulated within the tumors and the liver and lungs. These results provide a theoretical basis for future clinical applications.en_US
dc.rights© 2015 Elsevier.en_US
dc.subjectLiver tumorsen_US
dc.subjectPolymeric therapeutic nanoparticlesen_US
dc.subjectApoptosis pathwayen_US
dc.subjectCell membrane potentialen_US
dc.titleTargeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinomaen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US

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