N‑Heterocyclic Carbene-Catalyzed Radical Reactions for Highly Enantioselective β‑Hydroxylation of Enals
Webster, Richard D.
Chi, Robin Yonggui
Date of Issue2015
School of Physical and Mathematical Sciences
An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations. This oxidative single-electron-transfer reaction allows for highly enantioselective access to β-hydroxyl esters that are widely found in natural products and bioactive molecules.
Chemistry and Biological Chemistry
Journal of the American Chemical Society
© 2015 American Chemical Society (ACS).