dc.contributor.authorJackman, Joshua A.
dc.contributor.authorZan, Goh Haw
dc.contributor.authorZhao, Zhilei
dc.contributor.authorCho, Nam-Joon
dc.date.accessioned2016-06-09T03:44:07Z
dc.date.available2016-06-09T03:44:07Z
dc.date.issued2014
dc.identifier.citationJackman, J. A., Zan, G. H., Zhao, Z., & Cho, N.-J. (2014). Contribution of the Hydration Force to Vesicle Adhesion on Titanium Oxide. Langmuir, 30(19), 5368-5372.en_US
dc.identifier.issn0743-7463en_US
dc.identifier.urihttp://hdl.handle.net/10220/40637
dc.description.abstractTitanium oxide is a biocompatible material that supports vesicle adhesion. Depending on experimental parameters, adsorbed vesicles remain intact or rupture spontaneously. Vesicle rupture has been attributed to electrostatic attraction between vesicles and titanium oxide, although the relative contribution of various interfacial forces remains to be clarified. Herein, we investigated the influence of vesicle surface charge on vesicle adsorption onto titanium oxide and observed that electrostatic attraction is insufficient for vesicle rupture. Following this line of evidence, a continuum model based on the DLVO forces and a non-DLVO hydration force was applied to investigate the role of different interfacial forces in modulating the lipid–substrate interaction. Within an experimentally significant range of conditions, the model shows that the magnitude of the repulsive hydration force strongly influences the behavior of adsorbed vesicles, thereby supporting that the hydration force makes a strong contribution to the fate of adsorbed vesicles on titanium oxide. The findings are consistent with literature reports concerning phospholipid assemblies on solid supports and nanoparticles and underscore the importance of the hydration force in influencing the behavior of phospholipid films on hydrophilic surfaces.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofseriesLangmuiren_US
dc.rights© 2014 American Chemical Society.en_US
dc.subjectMaterials Science and Engineeringen_US
dc.subjectChemical and Biomedical Engineeringen_US
dc.titleContribution of the Hydration Force to Vesicle Adhesion on Titanium Oxideen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1021/la404581d


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