dc.contributor.authorMochizuki, Masahito
dc.contributor.authorOguchi, Masahiro
dc.contributor.authorKim, Seong-Oh
dc.contributor.authorJackman, Joshua Alexander
dc.contributor.authorOgawa, Tetsu
dc.contributor.authorLkhamsuren, Ganchimeg
dc.contributor.authorCho, Nam-Joon
dc.contributor.authorHayashi, Tomohiro
dc.date.accessioned2016-06-09T05:01:14Z
dc.date.available2016-06-09T05:01:14Z
dc.date.issued2015
dc.identifier.citationMochizuki, M., Oguchi, M., Kim, S.-O., Jackman, J. A., Ogawa, T., Lkhamsuren, G., et al. (2015). Quantitative Evaluation of Peptide–Material Interactions by a Force Mapping Method: Guidelines for Surface Modification. Langmuir, 31(29), 8006-8012.en_US
dc.identifier.issn0743-7463en_US
dc.identifier.urihttp://hdl.handle.net/10220/40648
dc.description.abstractPeptide coatings on material surfaces have demonstrated wide application across materials science and biotechnology, facilitating the development of nanobio interfaces through surface modification. A guiding motivation in the field is to engineer peptides with a high and selective binding affinity to target materials. Herein, we introduce a quantitative force mapping method in order to evaluate the binding affinity of peptides to various hydrophilic oxide materials by atomic force microscopy (AFM). Statistical analysis of adhesion forces and probabilities obtained on substrates with a materials contrast enabled us to simultaneously compare the peptide binding affinity to different materials. On the basis of the experimental results and corresponding theoretical analysis, we discuss the role of various interfacial forces in modulating the strength of peptide attachment to hydrophilic oxide solid supports as well as to gold. The results emphasize the precision and robustness of our approach to evaluating the adhesion strength of peptides to solid supports, thereby offering guidelines to improve the design and fabrication of peptide-coated materials.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofseriesLangmuiren_US
dc.rights© 2015 American Chemical Society.en_US
dc.subjectMaterials Science and Engineeringen_US
dc.subjectChemical and Biomedical Engineeringen_US
dc.titleQuantitative Evaluation of Peptide–Material Interactions by a Force Mapping Method: Guidelines for Surface Modificationen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1021/acs.langmuir.5b01691


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