dc.contributor.authorZhao, Xinxin
dc.contributor.authorLui, Yuan Siang
dc.contributor.authorChoo, Caleb Kai Chuen
dc.contributor.authorSow, Wan Ting
dc.contributor.authorHuang, Charlotte Liwen
dc.contributor.authorNg, Kee Woei
dc.contributor.authorTan, Lay Poh
dc.contributor.authorLoo, Joachim Say Chye
dc.identifier.citationZhao, X., Lui, Y. S., Choo, C. K. C., Sow, W. T., Huang, C. L., Ng, K. W., et al. (2015). Calcium phosphate coated Keratin–PCL scaffolds for potential bone tissue regeneration. Materials Science and Engineering: C, 49, 746-753.en_US
dc.description.abstractThe incorporation of hydroxyapatite (HA) nanoparticles within or on the surface of electrospun polymeric scaffolds is a popular approach for bone tissue engineering. However, the fabrication of osteoconductive composite scaffolds via benign processing conditions still remains a major challenge to date. In this work, a new method was developed to achieve a uniform coating of calcium phosphate (CaP) onto electrospun keratin–polycaprolactone composites (Keratin–PCL). Keratin within PCL was crosslinked to decrease its solubility, before coating of CaP. A homogeneous coating was achieved within a short time frame (~ 10 min) by immersing the scaffolds into Ca2 + and (PO4)3 − solutions separately. Results showed that the incorporation of keratin into PCL scaffolds not only provided nucleation sites for Ca2 + adsorption and subsequent homogeneous CaP surface deposition, but also facilitated cell–matrix interactions. An improvement in the mechanical strength of the resultant composite scaffold, as compared to other conventional coating methods, was also observed. This approach of developing a biocompatible bone tissue engineering scaffold would be adopted for further in vitro osteogenic differentiation studies in the future.en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.relation.ispartofseriesMaterials Science and Engineering: Cen_US
dc.rights© 2015 Elsevier.en_US
dc.titleCalcium phosphate coated Keratin–PCL scaffolds for potential bone tissue regenerationen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.organizationSingapore Centre for Environmental Life Sciences Engineeringen_US

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