Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/81987
Title: RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors
Authors: Wong, Queenie Wing-Lei
Li, Jia
Ng, Sheng Rong
Lim, Seng Gee
Yang, Henry
Vardy, Leah Karen Anne
Keywords: Ribosomal protein
RPL39L
Issue Date: 2013
Source: Wong, Q. W.-L., Li, J., Ng, S. R., Lim, S. G., Yang, H., & Vardy, L. A. (2013). RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors. RNA Biology, 11(1), 33-41.
Series/Report no.: RNA Biology
Abstract: Ribosomal proteins (RPs) have been shown to be able to impart selectivity on the translating ribosome implicating them in gene expression control. Many ribosomal proteins are highly conserved and recently a number of ribosomal protein paralogs have been described in mammals. We examined the expression pattern of RPs in differentiating mouse Embryonic Stem Cells (ESCs), paying particular attention to the RP paralogs. We find the RP paralog Rpl39l is highly expressed in ESC and its expression strongly correlates with hepatocellular carcinoma tumor (HCC) samples with high tumor grading and alpha-fetoprotein level giving it diagnostic potential. We further screen the expression pattern of all RPs and their paralogs across 22 different tissues. We find that the more recently evolved RP paralogs show a much greater level of tissue-specific expression. We propose that these RP paralogs evolved more recently to provide a greater level of gene expression control to higher eukaryotes.
URI: https://hdl.handle.net/10356/81987
http://hdl.handle.net/10220/41081
ISSN: 1547-6286
DOI: http://dx.doi.org/10.4161/rna.27427
Rights: © 2014 Landes Bioscience.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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