Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers

Author
Wong, Edgar H. H.
Khin, Mya Mya
Ravikumar, Vikashini
Si, Zhangyong
Rice, Scott A.
Chan-Park, Mary B.
Date of Issue
2016School
School of Chemical and Biomedical Engineering
School of Biological Sciences
School of Biological Sciences
Research Centre
Centre for Antimicrobial Bioengineering
Singapore Centre for Environmental Life Sciences Engineering
Singapore Centre for Environmental Life Sciences Engineering
Version
Accepted version
Abstract
The development of novel reagents and antibiotics for combating multidrug resistance bacteria has received significant attention in recent years. In this study, new antimicrobial star polymers (14–26 nm in diameter) that consist of mixtures of polylysine and glycopolymer arms were developed and were shown to possess antimicrobial efficacy toward Gram positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) (with MIC values as low as 16 μg mL–1) while being non-hemolytic (HC50 > 10 000 μg mL–1) and exhibit excellent mammalian cell biocompatibility. Structure function analysis indicated that the antimicrobial activity and mammalian cell biocompatibility of the star nanoparticles could be optimized by modifying the molar ratio of polylysine to glycopolymers arms. The technology described herein thus represents an innovative approach that could be used to fight deadly infectious diseases.
Subject
Mammalian cell
Biomacromolecules
Biomacromolecules
Type
Journal Article
Series/Journal Title
Biomacromolecules
Rights
© 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomacromolecules, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.biomac.5b01766].
http://dx.doi.org/10.1021/acs.biomac.5b01766
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