Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83400
Title: Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers
Authors: Wong, Edgar H. H.
Khin, Mya Mya
Ravikumar, Vikashini
Si, Zhangyong
Rice, Scott A.
Chan-Park, Mary B.
Keywords: Mammalian cell
Biomacromolecules
Issue Date: 2016
Source: Wong, E. H. H., Khin, M. M., Ravikumar, V., Si, Z., Rice, S. A., & Chan-Park, M. B. (2016). Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers. Biomacromolecules, 17(3), 1170-1178.
Series/Report no.: Biomacromolecules
Abstract: The development of novel reagents and antibiotics for combating multidrug resistance bacteria has received significant attention in recent years. In this study, new antimicrobial star polymers (14–26 nm in diameter) that consist of mixtures of polylysine and glycopolymer arms were developed and were shown to possess antimicrobial efficacy toward Gram positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) (with MIC values as low as 16 μg mL–1) while being non-hemolytic (HC50 > 10 000 μg mL–1) and exhibit excellent mammalian cell biocompatibility. Structure function analysis indicated that the antimicrobial activity and mammalian cell biocompatibility of the star nanoparticles could be optimized by modifying the molar ratio of polylysine to glycopolymers arms. The technology described herein thus represents an innovative approach that could be used to fight deadly infectious diseases.
URI: https://hdl.handle.net/10356/83400
http://hdl.handle.net/10220/41424
ISSN: 1525-7797
DOI: 10.1021/acs.biomac.5b01766
Rights: © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomacromolecules, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.biomac.5b01766].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles
SCBE Journal Articles
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