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|Title:||Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers||Authors:||Wong, Edgar H. H.
Khin, Mya Mya
Rice, Scott A.
Chan-Park, Mary B.
|Issue Date:||2016||Source:||Wong, E. H. H., Khin, M. M., Ravikumar, V., Si, Z., Rice, S. A., & Chan-Park, M. B. (2016). Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers. Biomacromolecules, 17(3), 1170-1178.||Series/Report no.:||Biomacromolecules||Abstract:||The development of novel reagents and antibiotics for combating multidrug resistance bacteria has received significant attention in recent years. In this study, new antimicrobial star polymers (14–26 nm in diameter) that consist of mixtures of polylysine and glycopolymer arms were developed and were shown to possess antimicrobial efficacy toward Gram positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) (with MIC values as low as 16 μg mL–1) while being non-hemolytic (HC50 > 10 000 μg mL–1) and exhibit excellent mammalian cell biocompatibility. Structure function analysis indicated that the antimicrobial activity and mammalian cell biocompatibility of the star nanoparticles could be optimized by modifying the molar ratio of polylysine to glycopolymers arms. The technology described herein thus represents an innovative approach that could be used to fight deadly infectious diseases.||URI:||https://hdl.handle.net/10356/83400
|ISSN:||1525-7797||DOI:||10.1021/acs.biomac.5b01766||Rights:||© 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomacromolecules, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.biomac.5b01766].||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SBS Journal Articles|
SCBE Journal Articles
SCELSE Journal Articles
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