dc.contributor.authorCho, Nam-Joon
dc.contributor.authorLee, Choongho
dc.contributor.authorPang, Phillip S.
dc.contributor.authorPham, Edward A.
dc.contributor.authorFram, Benjamin
dc.contributor.authorNguyen, Khanh
dc.contributor.authorXiong, Anming
dc.contributor.authorSklan, Ella H.
dc.contributor.authorElazar, Menashe
dc.contributor.authorKoytak, Elif S.
dc.contributor.authorKersten, Caroline
dc.contributor.authorKanazawa, Kay K.
dc.contributor.authorFrank, Curtis W.
dc.contributor.authorGlenn, Jeffrey S.
dc.identifier.citationCho, N. J., Lee, C., Pang, P. S., Pham, E. A., Fram, B., Nguyen, K., Xiong, A., Sklan, E. H., Elazar, M., Koytak, E. S., Kersten, C., Kanazawa, K. K., Frank, C. W., & Glenn, J. S. (2015). Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome. Gastroenterology, 148(3), 616-625.en_US
dc.description.abstractPhosphoinositides (PIs) bind and regulate localization of proteins via a variety of structural motifs. PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking. We investigated interactions between PI(4,5)P2 and hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and effects on the viral life cycle.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.subjectAntiviral Strategiesen_US
dc.subjectSignaling Moleculeen_US
dc.titlePhosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genomeen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Materials Science and Engineeringen_US

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