dc.contributor.authorPolizzi, Arnaud
dc.contributor.authorFouché, Edwin
dc.contributor.authorDucheix, Simon
dc.contributor.authorLasserre, Frédéric
dc.contributor.authorMarmugi, Alice P.
dc.contributor.authorMselli-Lakhal, Laila
dc.contributor.authorLoiseau, Nicolas
dc.contributor.authorWahli, Walter
dc.contributor.authorGuillou, Hervé
dc.contributor.authorMontagner, Alexandra
dc.date.accessioned2016-10-31T07:56:09Z
dc.date.available2016-10-31T07:56:09Z
dc.date.issued2016
dc.identifier.citationPolizzi, A., Fouché, E., Ducheix, S., Lasserre, F., Marmugi, A., Mselli-Lakhal, L., et al. (2016). Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids. International Journal of Molecular Sciences, 17(10), 1624-.en_US
dc.identifier.issn1661-6596en_US
dc.identifier.urihttp://hdl.handle.net/10220/41598
dc.description.abstractThe liver plays a central role in the regulation of fatty acid metabolism, which is highly sensitive to transcriptional responses to nutrients and hormones. Transcription factors involved in this process include nuclear hormone receptors. One such receptor, PPARα, which is highly expressed in the liver and activated by a variety of fatty acids, is a critical regulator of hepatic fatty acid catabolism during fasting. The present study compared the influence of dietary fatty acids and fasting on hepatic PPARα-dependent responses. Pparα(-/-) male mice and their wild-type controls were fed diets containing different fatty acids for 10 weeks prior to being subjected to fasting or normal feeding. In line with the role of PPARα in sensing dietary fatty acids, changes in chronic dietary fat consumption influenced liver damage during fasting. The changes were particularly marked in mice fed diets lacking essential fatty acids. However, fasting, rather than specific dietary fatty acids, induced acute PPARα activity in the liver. Taken together, the data imply that the potent signalling involved in triggering PPARα activity during fasting does not rely on essential fatty acid-derived ligand.en_US
dc.format.extent11 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesInternational Journal of Molecular Sciencesen_US
dc.rights© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectnuclear receptorsen_US
dc.subjectPPARαen_US
dc.titleHepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acidsen_US
dc.typeJournal Article
dc.identifier.doihttp://dx.doi.org/10.3390/ijms17101624
dc.description.versionPublished versionen_US
dc.contributor.organizationLee Kong Chian School of Medicineen_US


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