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https://hdl.handle.net/10356/84143
Title: | Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides | Authors: | Koh, Phay Chung | Keywords: | Antimicrobial peptide Immunogenicity |
Issue Date: | 2016 | Source: | Koh, P. C. (2016, March). Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. | Abstract: | Background: Bioactive peptides with antimicrobial properties have many potential applications, ranging from food preservation to the treatment of drug-resistant infections. However, some of these peptides may induce unwanted toxicity or immunogenicity. Regulatory agencies, therefore, require rigours safety assessments of all the therapeutic peptides using appropriate biological model systems. Our collaborating group has developed a novel series of AMPs with broad spectrum antimicrobial activities. Aim: To examine possible cytotoxicity and immunogenicity (if any) of the four AMPs (Pep 1, Pep 2, Pep 3, & Pep 4) using cell culture model systems. [2nd Award] | URI: | https://hdl.handle.net/10356/84143 http://hdl.handle.net/10220/41624 |
Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Rights: | © 2016 Author(s). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | URECA Posters |
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LKCM15014.pdf | 843.74 kB | Adobe PDF | View/Open |
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