Fabrication of complex hydrogel structure via free-form bioprinting: A review
Tan, Edgar Yong Sheng
Date of Issue2016
Proceedings of the 2nd International Conference on Progress in Additive Manufacturing (Pro-AM 2016)
School of Mechanical and Aerospace Engineering
Singapore Centre for 3D Printing
Different bioprinting techniques has been used in recent years to produce complex structures with hydrogels, however these approaches have been limited to simple 3 or 2.5 dimensional structures. This paper reviews the existing methods that are able to fabricate free-form complex shapes via bioprinting for tissue engineering purpose. The principle behind these free-form bioprinting techniques can be broadly categorized into 1) Providing a physical scaffolding or support structure that lifts the build material 2) Organizing complex cellular structures (termed tissue spheroids) in a controlled manner. The techniques reviewed are F.R.E.S.H. bioprinting, stereolithography, magnetic bioprinting and organovo extrusion based bioprinting. We discussed the processes critically in term of materials and resolution achieved by these techniques. The advantages and disadvantages of these techniques are presented as well.
© 2016 by Pro-AM 2016 Organizers. Published by Research Publishing, Singapore