dc.contributor.authorXie, Chen
dc.contributor.authorUpputuri, Paul Kumar
dc.contributor.authorZhen, Xu
dc.contributor.authorPramanik, Manojit
dc.contributor.authorPu, Kanyi
dc.identifier.citationXie, C., Upputuri, P. K., Zhen, X., Pramanik, M., & Pu, K. (2016). Self-quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imaging. Biomaterials, in press.
dc.description.abstractDevelopment of photoacoustic (PA) imaging agents provides opportunities for advancing PA imaging in fundamental biology and medicine. Despite the promise of semiconducting polymer nanoparticles (SPNs) for PA imaging, the molecular guidelines to enhance their imaging performance are limited. In this study, semiconducting polymers (SPs) with self-quenched fluorescence are synthesized and transformed into SPNs for amplified PA imaging in living mice. The self-quenched process is induced by the incorporation of an electron-deficient structure unit into the backbone of SPs, which in turn promotes the nonradiative decay and enhances the heat generation. Such a simple chemical alteration of SP eventually leads to 1.7-fold PA amplification for the corresponding SPN. By virtue of the targeting capability of cyclic-RGD, the amplified SPN can effectively delineate tumor in living mice and increase the PA intensity of tumor by 4.7-fold after systemic administration. Our study thus provides an effective molecular guideline to amplify the PA brightness of organic imaging agents for in vivo PA imaging.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent25 p.en_US
dc.rights© 2016 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomaterials, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.biomaterials.2016.12.004].en_US
dc.subjectPhotoacoustic imagingen_US
dc.subjectSemiconducting polymer nanoparticlesen_US
dc.titleSelf-quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imagingen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.versionAccepted versionen_US

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