dc.contributor.authorFang, Yiwen
dc.contributor.authorFullwood, Melissa Jane
dc.date.accessioned2016-12-16T08:46:38Z
dc.date.available2016-12-16T08:46:38Z
dc.date.issued2016
dc.identifier.citationFang, Y., & Fullwood, M. J. (2016). Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer. Genomics, Proteomics & Bioinformatics, 14(1), 42-54.en_US
dc.identifier.issn1672-0229en_US
dc.identifier.urihttp://hdl.handle.net/10220/41878
dc.description.abstractLong non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent13 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesGenomics, Proteomics & Bioinformaticsen_US
dc.rights© 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectlncRNAsen_US
dc.subjectChromatinen_US
dc.titleRoles, Functions, and Mechanisms of Long Non-coding RNAs in Canceren_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.gpb.2015.09.006
dc.description.versionPublished versionen_US


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