dc.contributor.authorLyu, Yan
dc.contributor.authorPu, Kanyi
dc.date.accessioned2017-02-27T06:04:08Z
dc.date.available2017-02-27T06:04:08Z
dc.date.copyright2017
dc.date.issued2017
dc.identifier.citationLyu, Y., & Pu, K. (2017). Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging. Advanced Science, 4(6), 1600481-.en_US
dc.identifier.urihttp://hdl.handle.net/10220/42128
dc.description.abstractMolecular probes that change their signals in response to the target of interest have a critical role in fundamental biology and medicine. Semiconducting polymer nanoparticles (SPNs) have recently emerged as a new generation of purely organic photonic nanoagents with desirable properties for biological applications. In particular, tunable optical properties of SPNs allow them to be developed into photoluminescence, chemiluminescence, and photoacoustic probes, wherein SPNs usually serve as the energy donor and internal reference for luminescence and photoacoustic probes, respectively. Moreover, facile surface modification and intraparticle engineering provide the versatility to make them responsive to various biologically and pathologically important substances and indexes including small-molecule mediators, proteins, pH and temperature. This article focuses on recent advances in the development of SPN-based activatable molecular probes for sensing and imaging. The designs and applications of these probes are discussed in details, and the present challenges to further advance them into life science are also analyzed.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent14 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesAdvanced Scienceen_US
dc.rights© 2017 The Authors (published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim). This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectActivatable probesen_US
dc.subjectNanoparticlesen_US
dc.titleRecent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imagingen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.1002/advs.201600481
dc.description.versionPublished versionen_US
dc.identifier.rims196113


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