Optimising probe holder design for sentinel lymph node imaging using clinical photoacoustic system with Monte Carlo simulation
Wen, Kew Kok
Date of Issue2017
Proceeding of SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017
School of Chemical and Biomedical Engineering
Photoacoustic tomography is a hybrid imaging modality that combines optical and ultrasound imaging. It is rapidly gaining attention in the field of medical imaging. The challenge is to translate it into a clinical setup. In this work, we report the development of a handheld clinical photoacoustic imaging system. A clinical ultrasound imaging system is modified to integrate photoacoustic imaging with the ultrasound imaging. Hence, light delivery has been integrated with the ultrasound probe. The angle of light delivery is optimized in this work with respect to the depth of imaging. Optimization was performed based on Monte Carlo simulation for light transport in tissues. Based on the simulation results, the probe holders were fabricated using 3D printing. Similar results were obtained experimentally using phantoms. Phantoms were developed to mimic sentinel lymph node imaging scenario. Also, in vivo sentinel lymph node imaging was done using the same system with contrast agent methylene blue up to a depth of 1.5 cm. The results validate that one can use Monte Carlo simulation as a tool to optimize the probe holder design depending on the imaging needs. This eliminates a trial and error approach generally used for designing a probe holder.
© 2017 Society of Photo-optical Instrumentation Engineers (SPIE). This paper was published in Proceeding of SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017 and is made available as an electronic reprint (preprint) with permission of SPIE. The published version is available at: http://dx.doi.org/10.1117/12.2250478. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.