Tailoring thin films for implant-specific applications
Steele, Terry W. J.
Loo, Joachim Say Chye
Venkatraman, Subbu S.
Date of Issue2016
School of Materials Science and Engineering
Research and development of polyester thin film implants can be tailored for controlled drug release, mechanical properties and surface properties. The high number of parameters often makes the optimization process slow and laborious. By employing high-throughput drug release and gradient-casting techniques, we show how these properties can be rapidly optimized. The employment of these techniques has yielded methods in which drug release can be tailored without the use of additives and how the choice of certain additives can change material properties while negligibly affecting drug release. Alternatively, plasma post-treatment may allow tailoring of thin film material properties though the judicious use of plasmas such as oxygen, argon, or a combination of them.
© 2016 Elsevier Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication in Thin Film Coatings for Biomaterials and Biomedical Applications, published by Woodhead Publishing on behalf of Elsevier Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/B978-1-78242-453-6.00003-1].