dc.contributor.authorChotirmall, Sanjay Haresh
dc.contributor.authorGellatly, Shaan L.
dc.contributor.authorBudden, Kurtis F.
dc.contributor.authorMac Aogáin, Micheál
dc.contributor.authorShukla, Shakti D.
dc.contributor.authorWood, David L.A.
dc.contributor.authorHugenholtz, Philip
dc.contributor.authorPethe, Kevin
dc.contributor.authorHansbro, Philip M.
dc.identifier.citationChotirmall, S. H., Gellatly, S. L., Budden, K. F., Mac Aogáin, M., Shukla, S. D., Wood, D. L. A., et al. (2017). Microbiomes in respiratory health and disease: An Asia-Pacific perspective. Respirology, 22(2), 240-250.en_US
dc.description.abstractThere is currently enormous interest in studying the role of the microbiome in health and disease. Microbiome's role is increasingly being applied to respiratory diseases, in particular COPD, asthma, cystic fibrosis and bronchiectasis. The changes in respiratory microbiomes that occur in these diseases and how they are modified by environmental challenges such as cigarette smoke, air pollution and infection are being elucidated. There is also emerging evidence that gut microbiomes play a role in lung diseases through the modulation of systemic immune responses and can be modified by diet and antibiotic treatment. There are issues that are particular to the Asia-Pacific region involving diet and prevalence of specific respiratory diseases. Each of these issues is further complicated by the effects of ageing. The challenges now are to elucidate the cause and effect relationships between changes in microbiomes and respiratory diseases and how to translate these into new treatments and clinical care. Here we review the current understanding and progression in these areas.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.description.sponsorshipMOH (Min. of Health, S’pore)en_US
dc.format.extent33 p.en_US
dc.rights© 2017 Asian Pacific Society of Respirology. This is the author created version of a work that has been peer reviewed and accepted for publication by Respirology, Asian Pacific Society of Respirology. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [ttp://dx.doi.org/10.1111/resp.12971].en_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.titleMicrobiomes in respiratory health and disease: An Asia-Pacific perspectiveen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicineen_US
dc.description.versionAccepted versionen_US

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