dc.contributor.authorTang, Tommy Hing-Cheung
dc.contributor.authorAlonso, Sylvie
dc.contributor.authorNg, Lisa Fong-Poh
dc.contributor.authorThein, Tun-Linn
dc.contributor.authorPang, Vincent Jun-Xiong
dc.contributor.authorLeo, Yee-Sin
dc.contributor.authorLye, David Chien-Boon
dc.contributor.authorYeo, Tsin-Wen
dc.date.accessioned2017-05-17T07:53:08Z
dc.date.available2017-05-17T07:53:08Z
dc.date.issued2017
dc.identifier.citationTang, T. H. -C., Alonso, S., Ng, L. F. -P., Thein, T. -L., Pang, V. J. -X., Leo, Y. -S., et al. (2017). Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity. Scientific Reports, 7, 46191-.en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://hdl.handle.net/10220/42446
dc.description.abstractPlasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever screened for dengue by RT-PCR or NS1 antigen testing was performed. Patients were assessed daily while symptomatic and at convalescence.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.format.extent9 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesScientific Reportsen_US
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_US
dc.subjectSerum hyaluronic acid (HA)en_US
dc.subjectPlasma Leakageen_US
dc.titleIncreased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severityen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicineen_US
dc.identifier.doihttp://dx.doi.org/10.1038/srep46191
dc.description.versionPublished versionen_US


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