dc.contributor.authorDegirmenci, Ufuk
dc.contributor.authorLei, Sun
dc.date.accessioned2017-05-24T02:02:49Z
dc.date.available2017-05-24T02:02:49Z
dc.date.issued2016
dc.identifier.citationDegirmenci, U.,& Lei, S. (2016). Role of lncRNAs in Cellular Aging. Frontiers in Endocrinology, 7.en_US
dc.identifier.issn1664-2392en_US
dc.identifier.urihttp://hdl.handle.net/10220/42475
dc.description.abstractAging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level. Understanding the molecular mechanism underlying senescence could facilitate the development of potential therapeutics for aging and age-related diseases. Recently, the discovery of long non-coding RNAs (lncRNA) provided insights into a novel regulatory layer that can intervene with cellular senescence. Increasing evidence indicates that targeting lncRNAs may impact on senescence pathways. In this review, we will focus on lncRNAs involved in mechanistic pathways governing cellular senescence.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.format.extent10 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesFrontiers in Endocrinologyen_US
dc.rights© 2016 Degirmenci and Lei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectSenescenceen_US
dc.subjectAgingen_US
dc.subjectlncRNAen_US
dc.titleRole of lncRNAs in Cellular Agingen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doihttp://dx.doi.org/10.3389/fendo.2016.00151
dc.description.versionPublished versionen_US


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