Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature
Hong, Eun Young
Date of Issue2016
School of Materials Science and Engineering
A novel thermostable ω-transaminase from Thermomicrobium roseum which showed broad substrate specificity and high enantioselectivity was identified, expressed and biochemically characterized. The advantage of this enzyme to remove volatile inhibitory by-products was demonstrated by performing asymmetric synthesis and kinetic resolution at high temperature.
© 2016 The Royal Society of Chemistry