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Title: | The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms | Authors: | Kovács, Tibor Billes, Viktor Komlós, Marcell Hotzi, Bernadette Manzéger, Anna Tarnóci, Anna Papp, Diána Szikszai, Fanni Szinyákovics, Janka Rácz, Ákos Noszál, Béla Veszelka, Szilvia Walter, Fruzsina R. Deli, Mária A. Hackler, Laszlo Alfoldi, Robert Huzian, Orsolya Puskas, Laszlo G. Liliom, Hanna Tárnok, Krisztián Schlett, Katalin Borsy, Adrienn Welker, Ervin Kovács, Attila L. Pádár, Zsolt Erdős, Attila Legradi, Adam Bjelik, Annamaria Gulya, Károly Gulyás, Balázs Vellai, Tibor |
Keywords: | Drug discovery Diseases |
Issue Date: | 2017 | Source: | Kovács, T., Billes, V., Komlós, M., Hotzi, B., Manzéger, A., Tarnóci, A., et al. (2017). The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Scientific Reports, 7, 42014-. | Series/Report no.: | Scientific Reports | Abstract: | Autophagy functions as a main route for the degradation of superfluous and damaged constituents of the cytoplasm. Defects in autophagy are implicated in the development of various age-dependent degenerative disorders such as cancer, neurodegeneration and tissue atrophy, and in accelerated aging. To promote basal levels of the process in pathological settings, we previously screened a small molecule library for novel autophagy-enhancing factors that inhibit the myotubularin-related phosphatase MTMR14/Jumpy, a negative regulator of autophagic membrane formation. Here we identify AUTEN-99 (autophagy enhancer-99), which activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson’s and Huntington’s diseases. Furthermore, the molecule increases the survival of isolated neurons under normal and oxidative stress-induced conditions. Thus, AUTEN-99 serves as a potent neuroprotective drug candidate for preventing and treating diverse neurodegenerative pathologies, and may promote healthy aging. | URI: | https://hdl.handle.net/10356/83587 http://hdl.handle.net/10220/42675 |
ISSN: | 2045-2322 | DOI: | 10.1038/srep42014 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Rights: | © 2017 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
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The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms.pdf | 2.7 MB | Adobe PDF | View/Open |
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