Long-Term Real-Time In Vivo Drug Release Monitoring with AIE Thermogelling Polymer
Liow, Sing Shy
Yu, Chris Yee Yung
Kwok, Ryan Tsz Kin
Ong, Seow Theng
Verma, Navin Kumar
Tang, Ben Zhong
Loh, Xian Jun
Date of Issue2016
Lee Kong Chian School of Medicine
A new drug concentration meter is developed. In vivo drug release can be monitored precisely via a self-indicating drug delivery system consisting of a new aggregation-induced emission thermoresponsive hydrogel. By taking the advantage of a self-indicating system, one can easily detect the depletion of drugs, and reinject to maintain a dosage in the optimal therapeutic window.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Small, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/smll.201603404].