dc.contributor.authorLiow, Sing Shy
dc.contributor.authorZhou, Hui
dc.contributor.authorSugiarto, Sigit
dc.contributor.authorGuo, Shifeng
dc.contributor.authorChalasani, Madhavi Latha S.
dc.contributor.authorVerma, Navin Kumar
dc.contributor.authorXu, Jianwei
dc.contributor.authorLoh, Xian Jun
dc.identifier.citationLiow, S. S., Zhou, H., Sugiarto, S., Guo, S., Chalasani, M. L. S., Verma, N. K., et al. (2017). Highly Efficient Supramolecular Aggregation-Induced Emission-Active Pseudorotaxane Luminogen for Functional Bioimaging. Biomacromolecules, 18(3), 886-897.en_US
dc.description.abstractThe direct tracking of cells using fluorescent dyes is a constant challenge in cell therapy due to aggregation-induced quenching (ACQ) effect and biocompatibility issues. Here, we demonstrate the development of a biocompatible and highly efficient aggregation-induced emission (AIE)-active pseudorotaxane luminogen based on tetraphenylethene conjugated poly(ethylene glycol) (TPE-PEG2) (guest) and α-cyclodextrin (α-CD) (host). It is capable of showing significant fluorescent emission enhancement at the 400-600 nm range when excited at 388 nm, without increasing the concentration of AIE compound. The fluorescent intensity of TPE-PEG2 solution was effectively enhanced by 4-12 times with gradual addition of 1-4 mM of α-CD. 2D NOSEY 1H NMR revealed clear correlation spots between the characteristic peaks of α-CD and PEG, indicating the interaction between protons of ethylene glycol and cyclodextrin, and the structures are mainly based on threaded α-CD. The host-guest complex exhibits boosted fluorescent emission because the PEG side chains are confined in "nano-cavities" (host), thus, applying additional restriction on intermolecular rotation of TPE segments. In vitro cell experiments demonstrated the potential of AIE-active pseudorotaxane polymer as a biocompatible bioimaging probe.en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.format.extent30 p.en_US
dc.rights© 2017 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomacromolecules, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.biomac.6b01777].en_US
dc.subjectAggregation-induced emissionsen_US
dc.subjectHost guest complexesen_US
dc.titleHighly Efficient Supramolecular Aggregation-Induced Emission-Active Pseudorotaxane Luminogen for Functional Bioimagingen_US
dc.typeJournal Article
dc.contributor.schoolLee Kong Chian School of Medicineen_US
dc.description.versionAccepted versionen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record