dc.contributor.authorLi, Jianguo
dc.contributor.authorKoh, Jun-Jie
dc.contributor.authorLiu, Shouping
dc.contributor.authorLakshminarayanan, Rajamani
dc.contributor.authorVerma, Chandra Shekhar
dc.contributor.authorBeuerman, Roger W.
dc.date.accessioned2017-06-16T08:18:41Z
dc.date.available2017-06-16T08:18:41Z
dc.date.issued2017
dc.identifier.citationLi, J., Koh, J.-J., Liu, S., Lakshminarayanan, R., Verma, C. S., & Beuerman, R. W. (2017). Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design. Frontiers in Neuroscience, 11, 73-.en_US
dc.identifier.issn1662-4548en_US
dc.identifier.urihttp://hdl.handle.net/10220/42720
dc.description.abstractAntimicrobial peptides (AMPs) are promising next generation antibiotics that hold great potential for combating bacterial resistance. AMPs can be both bacteriostatic and bactericidal, induce rapid killing and display a lower propensity to develop resistance than do conventional antibiotics. Despite significant progress in the past 30 years, no peptide antibiotic has reached the clinic yet. Poor understanding of the action mechanisms and lack of rational design principles have been the two major obstacles that have slowed progress. Technological developments are now enabling multidisciplinary approaches including molecular dynamics simulations combined with biophysics and microbiology toward providing valuable insights into the interactions of AMPs with membranes at atomic level. This has led to increasingly robust models of the mechanisms of action of AMPs and has begun to contribute meaningfully toward the discovery of new AMPs. This review discusses the detailed action mechanisms that have been put forward, with detailed atomistic insights into how the AMPs interact with bacterial membranes. The review further discusses how this knowledge is exploited toward developing design principles for novel AMPs. Finally, the current status, associated challenges, and future directions for the development of AMP therapeutics are discussed.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.format.extent18 p.en_US
dc.language.isoenen_US
dc.relation.ispartofseriesFrontiers in Neuroscienceen_US
dc.rights© 2017 Li, Koh, Liu, Lakshminarayanan, Verma and Beuerman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectAntimicrobial peptidesen_US
dc.subjectAction mechanismen_US
dc.titleMembrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Designen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doihttp://dx.doi.org/10.3389/fnins.2017.00073
dc.description.versionPublished versionen_US


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