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      Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging

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      Ultralong Phosphorescence of Water-soluble Organic Nanoparticles for In Vivo Afterglow Imaging.pdf (1.377Mb)
      Author
      Zhen, Xu
      Tao, Ye
      An, Zhongfu
      Chen, Peng
      Xu, Chenjie
      Chen, Runfeng
      Huang, Wei
      Pu, Kanyi
      Date of Issue
      2017
      School
      School of Chemical and Biomedical Engineering
      Version
      Accepted version
      Abstract
      Afterglow or persistent luminescence eliminates the need for light excitation and thus circumvents the issue of autofluorescence, holding promise for molecular imaging. However, current persistent luminescence agents are rare and limited to inorganic nanoparticles. This study reports the design principle, synthesis, and proof-of-concept application of organic semiconducting nanoparticles (OSNs) with ultralong phosphorescence for in vivo afterglow imaging. The design principle leverages the formation of aggregates through a top-down nanoparticle formulation to greatly stabilize the triplet excited states of a phosphorescent molecule. This prolongs the particle luminesce to the timescale that can be detected by the commercial whole-animal imaging system after removal of external light source. Such ultralong phosphorescent of OSNs is inert to oxygen and can be repeatedly activated, permitting imaging of lymph nodes in living mice with a high signal-to-noise ratio. This study not only introduces the first category of water-soluble ultralong phosphorescence organic nanoparticles but also reveals a universal design principle to prolong the lifetime of phosphorescent molecules to the level that can be effective for molecular imaging.
      Subject
      Afterglow
      Lymph Node Imaging
      Type
      Journal Article
      Series/Journal Title
      Advanced Materials
      Rights
      © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Materials, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://doi.org/10.1002/adma.201606665].
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      http://doi.org/10.1002/adma.201606665
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