dc.contributor.authorMcGeachie, Michael J.
dc.contributor.authorYates, Katherine P.
dc.contributor.authorZhou, Xiaobo
dc.contributor.authorGuo, Feng
dc.contributor.authorSternberg, Alice L.
dc.contributor.authorVan Natta, Mark L.
dc.contributor.authorWise, Robert A.
dc.contributor.authorSzefler, Stanley J.
dc.contributor.authorSharma, Sunita
dc.contributor.authorKho, Alvin T.
dc.contributor.authorCho, Michael H.
dc.contributor.authorCroteau-Chonka, Damien C.
dc.contributor.authorCastaldi, Peter J.
dc.contributor.authorJain, Gaurav
dc.contributor.authorSanyal, Amartya
dc.contributor.authorZhan, Ye
dc.contributor.authorLajoie, Bryan R.
dc.contributor.authorDekker, Job
dc.contributor.authorStamatoyannopoulos, John
dc.contributor.authorCovar, Ronina A.
dc.contributor.authorZeiger, Robert S.
dc.contributor.authorAdkinson, N. Franklin
dc.contributor.authorWilliams, Paul V.
dc.contributor.authorKelly, H. William
dc.contributor.authorGrasemann, Hartmut
dc.contributor.authorVonk, Judith M.
dc.contributor.authorKoppelman, Gerard H.
dc.contributor.authorPostma, Dirkje S.
dc.contributor.authorRaby, Benjamin A.
dc.contributor.authorHouston, Isaac
dc.contributor.authorLu, Quan
dc.contributor.authorFuhlbrigge, Anne L.
dc.contributor.authorTantisira, Kelan G.
dc.contributor.authorSilverman, Edwin K.
dc.contributor.authorTonascia, James
dc.contributor.authorStrunk, Robert C.
dc.contributor.authorWeiss, Scott T.
dc.identifier.citationMcGeachie, M. J., Yates, K. P., Zhou, X., Guo, F., Sternberg, A. L., Van Natta, M. L., et al. (2016). Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. American Journal of Respiratory and Critical Care Medicine, 194(12), 1465-1474.en_US
dc.description.abstractRationale: Patterns of longitudinal lung function growth and decline in childhood asthma have been shown to be important in determining risk for future respiratory ailments including chronic airway obstruction and chronic obstructive pulmonary disease. Objectives: To determine the genetic underpinnings of lung function patterns in subjects with childhood asthma. Methods: We performed a genome-wide association study of 581 non-Hispanic white individuals with asthma that were previously classified by patterns of lung function growth and decline (normal growth, normal growth with early decline, reduced growth, and reduced growth with early decline). The strongest association was also measured in two additional cohorts: a small asthma cohort and a large chronic obstructive pulmonary disease metaanalysis cohort. Interaction between the genomic region encompassing the most strongly associated single-nucleotide polymorphism and nearby genes was assessed by two chromosome conformation capture assays. Conclusions: Early decline in lung function after normal growth is associated with a genetic polymorphism that may also protect against early decline in reduced growth groups.en_US
dc.format.extent127 p.en_US
dc.relation.ispartofseriesAmerican Journal of Respiratory and Critical Care Medicineen_US
dc.rights© 2016 American Thoracic Society (ATS). This is the author created version of a work that has been peer reviewed and accepted for publication by American Journal of Respiratory and Critical Care Medicine, American Thoracic Society (ATS). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1164/rccm.201602-0250OC].en_US
dc.titleGenetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthmaen_US
dc.typeJournal Article
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.schoolLee Kong Chian School of Medicineen_US
dc.description.versionAccepted versionen_US

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